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pentobarbital will lower the level or result of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will reduce the level or result of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.pentobarbital will reduce the level or effect of vinorelbine